منابع مشابه
[Proteomics and cardiovascular disease].
The description of the human genome has opened new venues for the study and understanding of pathophysiological phenomena. In the 20th century, individual cell components were studied. The 21st century began with a global analysis of cell components. Thanks to the development of new technologies such as DNA chips, or two-dimensional electrophoresis, we can now study the expression of thousands ...
متن کاملCardiovascular proteomics: evolution and potential.
The development of proteomics is a timely one for cardiovascular research. Analyses at the organ, subcellular, and molecular levels have revealed dynamic, complex, and subtle intracellular processes associated with heart and vascular disease. The power and flexibility of proteomic analyses, which facilitate protein separation, identification, and characterization, should hasten our understandin...
متن کاملAdvancing cardiovascular biology and medicine via proteomics: Opportunities and present challenges of cardiovascular proteomics.
The successful advancement of biology and medicine necessitates a comprehensive and integrative understanding of the proteome in a healthy individual and, through inference, the identification of those proteins considered to be abnormal and to potentially herald disease. Protein markers, complementary to gene markers, constitute the molecular basis for personalized medicine. Given the enormity ...
متن کاملProteomics in cardiovascular biology and medicine.
The sequencing of the human genome is undoubtedly one of the major accomplishments of biomedical science.1,2 Knowledge of the precise sequence of all human genes provides unparalleled access to a complete understanding of human biology in all of its complexity. Or does it? The completion of the human genome sequence showed far fewer genes than expected, 30 000, which is not that different from ...
متن کاملVascular proteomics in metabolic and cardiovascular diseases
The vasculature is essential for proper organ function. Many pathologies are directly and indirectly related to vascular dysfunction, which causes significant morbidity and mortality. A common pathophysiological feature of diseased vessels is extracellular matrix (ECM) remodelling. Analysing the protein composition of the ECM by conventional antibody-based techniques is challenging; alternative...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2006
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2006.06.063